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Bone Diseases: Macroscopic, Histological, and Radiological by Claus-Peter Adler

By Claus-Peter Adler

The booklet offers a complete description of macroscopic, microscopic, and radiological equipment for the prognosis of bone illnesses. It offers the entire approaches serious about analysis, utilizing not just radiological and histological suggestions, but additionally smooth immunohistochemical and scintigraphic tools. Succinct and well-structured healing techniques are supplied for an array of bone ailments. A practice-oriented reference paintings for pathologists, radiologists, rheumatologists, and orthopedists.

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Additional info for Bone Diseases: Macroscopic, Histological, and Radiological Diagnosis of Structural Changes in the Skeleton

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They mature to form osteoblasts, which are the true builders of bone. They produce collagen fibrils and especially osteoid, the initially uncalcified ground substance of bone, and each is capable of laying down approximate1y three times its own volume of bone matrix. The formation of collagen is a purely basal process, making the building up of an organized structure possible. The process of calcification of bony tissue requires a high concentration of alkaline phosphatase in the osteoblasts, and in the presence of osteoblastic activity this is also found in the serum.

The Blood Supply of Bone 4 2 - - -----'-'" Fig. 20. Spongiosa of normal vertebra (maceration specimen) Fig. 21. Spongiosa of normal vertebra; HE, x 20 ~""-- 5 5 3 ~'\--- 10 6 ~--- 9 2 '---"----- 4 Fig. 22. Diagram showing the blood supply of a bone (after BROOKES 1971) Fig. 23. Normal intraosseous angiogram (proximal tibia) 17 18 2 Normal Anatomy and Histology Histological Structure of Bone Bone is a mesenchymal tissue the cells of which possess and retain the capacity for proliferation and differentiation.

Histological identification of cancellous bone depends upon the normally regular structural network of the bone trabeculae and the areas of marrow cavity, more or less of equal size, lying between them. As can be seen in Fig. 33, the cancellous trabeculae are almost equal in width (1) and the marrow cavity (2) is so wide that it and the bone tissue are virtually coextensive. Under higher magnification (Fig. 34) it can be seen that the cancellous trabeculae mostly have smooth edges (1) and are not covered by osteoblasts or osteoclasts.

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