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Bone and Joint Infections: From Microbiology to Diagnostics by W. Zimmerli

By W. Zimmerli

Bone and Joint Infections is the 1st booklet to take a multidisciplinary method of protecting the factors and therapy of osteomyelitis and septic arthritis. right and speedy analysis of bone and joint an infection calls for the enter of a number of experts, and Bone and Joint Infection takes a similarly collaborative and comprehensive approach, together with chapters from a diverse staff of clinicians, researchers, and surgeons.

Covering either the fundamental microbiology and medical features of bone and joint an infection, this e-book should be a priceless source either for researchers within the lab and for physicians and surgeons looking a complete reference on osteomyelitis and septic arthritis.

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Additional resources for Bone and Joint Infections: From Microbiology to Diagnostics and Treatment

Sample text

Lack of microbiological concordance between bone and non-bone specimens in chronic osteomyelitis: an observational study. BMC Infect Dis 2002;2;8. [9] Fantoni M, Trecarichi EM, Rossi B, et al. Epidemiological and clinical features of pyogenic spondylodiscitis. Eur Rev Med Pharmacol Sci 2012;16(Suppl 2):2–7. [10] Mete B, Kurt C, Yilmaz MH, et al. Vertebral osteomyelitis: eight years’ experience of 100 cases. Rheumatol Int 2012;32(11):3591–3597. [11] Alavi SM, Sharifi M. Tuberculous spondylitis: risk factors and clinical/paraclinical aspects in the south west of Iran.

Novel Diagnostic Procedures Matrix-assisted laser desorption ionization time-of-flight analysis mass spectrometry (MALDI–TOF MS) is a relatively new technology that provides fast, accurate, and relatively inexpensive identification of bacteria and fungi growing in culture [55]. 5% trifluoroacetic acid). The plate is dried and placed into the chamber of a mass spectrometer, in which the dried spot is hit by a laser. The matrix protects the microbial proteins, and aids in desorbing and ionizing microbial proteins (primarily highly abundant ribosomal proteins).

The condition of the bone samples is likely more homogeneous among joint replacement patients than patients with various stages and locations of bone infections; therefore, results of different studies can be more readily compared. However, antibiotic concentrations might differ between infected and uninfected bone. Reactive hyperemia could increase the blood flow into bone, whereas pus or sequesters might limit the distribution of 24 Bone and Joint Infections a­ ntibiotics into bone. To date, few studies have been performed in patients with bone infections, which does not enable a systematic comparison of penetration between infected and uninfected bone.

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