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Autoimmune Bullous Diseases: Approach and Management by Naveed Sami

By Naveed Sami

This booklet specializes in aiding either dermatologists and non-dermatologists process the therapy of every illness in a practical demeanour. every one bankruptcy experiences the present literature of remedies for every ailment, score disorder severity, and offers pragmatic guidance in response to ailment severity at the utilization of accessible medicines. the present literature doesn't supply potent instructions. This publication addresses this deficiency. This ebook may help consultant clinicians in imposing acceptable remedies in line with the categorical sickness and its severity, and attainable possible choices in an algorithmic layout. it'll make the administration of those illnesses extra pragmatic in response to either the literature and scientific adventure of experts.

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Iraji F, Asilian A, Siadat AH. Pimecrolimus 1% cream in the treatment of cutaneous lesions of pemphigus vulgaris: a double-blind, placebo-controlled clinical trial. J Drugs Dermatol. 2010;9:684–6. 15. Cohen SN, Lim RP, Paul CJ, Abdullah A. Equal efficacy of topical tacrolimus and clobetasone butyrate in pemphigus foliaceus. Int J Dermatol. 2006;45:1379. 16. Tabrizi MN, Chams-Davatchi C, Esmaeeli N, et al. Accelerating effects of epidermal growth factor on skin lesions of pemphigus vulgaris: a double-blind, randomized, controlled trial.

Of the 13 patients treated with RTX, 9 achieved complete remission 3-months after 1 RTX cycle. Thereafter, 7 patients (4 with maintenance therapy) relapsed within a mean of 18-months after the last RTX cycle and received 1 or 2 additional RTX cycles. Mean follow-up was 41-months after the first cycle and 28-months after the last. All 13 patients remained in complete remission (5 patients off therapy). Cianchini et al. 5-months. Leshem et al. [72] reported a total of 47 patients with pemphigus (42 PV, 3 PF) (2 discontinued due to infusion reactions 32 K.

N Engl J Med. 1982;306:1189–96. 6. Amagai M, Klaus-Kovtun V, Stanley JR. Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion. Cell. 1991;67:869–77. 7. Koch PJ, Mahoney MG, Ishikawa H, et al. Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris. J Cell Biol. 1997;137:1091–102. 8. Yamamoto T, Ikeda K, Sasaoka S, et al. Human leukocyte antigen genotypes and antibody profiles associated with familial pemphigus in Japanese.

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