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Abnormal Embryogenesis: Cellular and Molecular Aspects by Patricia A. Martin-Deleon, Evelyn L. Shaver (auth.), T. V.

By Patricia A. Martin-Deleon, Evelyn L. Shaver (auth.), T. V. N. Persaud (eds.)

The learn of delivery defects has assumed an significance even higher now than long ago simply because mortality premiums attributed to congenital anomalies have declined a ways under these for different reasons of loss of life, akin to infectious and dietary illnesses. it's expected that as many as 50% of all pregnancies terminate as miscarriages. within the majority of circumstances this can be the results of defective improvement. significant congenital malformations are present in not less than 2% of all liveborn babies, and 22% of all stillbirths and youngster deaths are linked to serious congenital anomalies. Teratological reviews of an experimental nature are neither moral nor justifiable in people. quite a few investigations were performed in laboratory animals and different experimental types with a view to enhance our knowing of irregular intrauterine improvement. In under twenty years the sphere of experimental teratology has complicated phenomenally. as a result of wide variety of data that's now amassing, it has develop into attainable to acquire an perception into the motives, mechanisms, and prevention of beginning defects. even if, significant paintings might be wanted sooner than those difficulties may be resolved. The comributions during this quantity comprise the various newer and intriguing observations at the mobile and molecular features of developmental defects. it isn't just a documentation of the most recent experimental paintings, however it additionally shows new and critical parts for destiny research.

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Sister chromatid exchanges induced by mitomycin C: a new method of detecting DNA damage at chromosomal level. Mutat. , 28, 459 Kram, D. and Schneider, E. L. (1978). Reduced frequencies of mitomycin C induced sister chromatid exchanges in AKR mice. Hum. , 41, 45 Vogel, W. and Bauknecht, T. (1976). Differential chromatid staining by in vivo treatment as a mutagenicity test system. Nature, 260, 448 Solomon, E. and Bobrow, M. (1975). Sister chromatid exchange - a sensitive assay of agents damaging human chromosomes.

The increase in collagen synthesis was manifested both in terms of increased incorporation into the collagen sequence as assayed by the use of collagenase and by the increased formation of radioactive hydroxyproline. Examination of the nature of the collagen chains synthesized in the presence of the stimulating agents showed that only the cartilage specific Type II collagen was synthesized under 36 ROLE OF COLLAGEN IN TERATOGENESIS all conditions. Our studies confirm the role of metabolic factors in regulating collagen synthesis and suggest that the modulation of collagen synthesis may be linked to the process of teratogenesis.

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